PhD in molecular microbiology: Unraveling mutational robustness and evolvability in bacteria

Job title:

PhD in molecular microbiology: Unraveling mutational robustness and evolvability in bacteria

Company

VIB

Job description

The lab of Jan Michiels is embedded within the VIB (Flemish Institute for Biotechnology) Center for Microbiology and the KU Leuven (University of Leuven) Centre of Microbial and Plant Genetics. The group studies bacterial survival under various stressful conditions, please see https://michielslab.sites.vib.be/en [https://michielslab.sites.vib.be/en] for more information. The lab currently consists of ~20 junior lab researchers and is looking for a dynamic and highly motivated PhD student.Research topic
Whereas mutations are the driving force for adaptive evolution, many genetic alterations exert negative fitness effects. The effect of some mutations can be buffered by the activity of specific genes encoded elsewhere in the genome. These so-called buffering genes give rise to mutational robustness which implies that a phenotype remains invariant in spite of mutations to its genotype, thereby diminishing the organism’s capacity to adapt to new environments. At present, mutational robustness and evolvability remain poorly understood.
In collaboration with the candidate, a detailed research plan will be drafted aiming to unravel mutational robustness and evolvability in Escherichia coli. The work will involve genome editing (CRISPR), genetics (genome sequencing), bioinformatics and single-cell (microscopy, microfluidics, FACS) analyses of E. coli bacteria and will be centred around the following themes:
Pathways involved in robustness against de novo mutationsType of genetic variation that can be buffered
Molecular mechanisms underlying mutational robustnessSkills
Essential
The candidate holds a Master degree in bioengineering science, (bio)chemistry, (molecular) biology or biotechnology with the equivalent of at least distinction (15/20 on the Belgian scale)
The candidate has a critical and creative mindThe candidate is a true problem solver with a proficiency to overcome technical challenges
The candidate is a team player with good communication skills
Proficient use of the English language for both oral and written communication
Desirable but not required
Computational background is a plus
Key personal characteristics
Motivated & enthused team player who enjoys working in a fun, diverse multicultural teamWe offer
A full-time PhD position for one year; after a positive evaluation, the contract can be extended to three additional years (four years in total)A working climate where trust, (international) collaboration, and commitment are essentialAn excellent young, stimulating and supportive international research environmentHigh level scientific training at a top-ranked university; training in academic, thematic and soft skills.
Access to state-of-the art tools and infrastructureHow to apply?
Applications should be submitted through this portal by July 7th 2025 and should contain:
Full CV including previous research experience and publication list (if applicable)Concise cover letter describing your motivation and career goalsList of two references (e.g. master thesis promoter and/or supervisor) with emails and phone numbersTranscripts of your bachelor and master studies including all classes followed and marks obtained
For more info please contact dr. Natalie Verstraeten (natalie.verstraeten@kuleuven.be) or prof. Jan Michiels (jan.michiels@kuleuven.be)

Expected salary

Location

Leuven, Vlaams Brabant

Job date

Tue, 13 May 2025 22:50:31 GMT

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