Postdoc in Aging Biology

Titlul postului:

Companie

Syddansk Universitet

Descrierea postului

Job Category: VIPJob Description:at the University of Southern Denmark (SDU) invites applications for a fully funded postdoctoral position in aging biology, based in the laboratory of .IMM is a leading interdisciplinary research center focused on understanding human biology and disease, with key strengths in neurobiology, cancer, and aging.The position is available from June 15, 2025 or as soon as possible thereafter and for an initial period of 6 months, with the possibility of extension up to 2 years.Research focusDr. Sahu’s lab investigates the molecular mechanisms underlying aging, with particular emphasis on Senescence-Associated Secretory Phenotype (SASP). Their research explores how SASP contributes to aging-related diseases and aims to develop therapeutic strategies to mitigate its harmful effects while preserving its beneficial functions. The lab also works on cellular rejuvenation through partial reprogramming techniques to reverse age-related decline in health, focusing on improving healthspan and organ function in aging models.Key recent publications from Dr. Sahu’s previous work include:

Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging. Science Translational Medicine, Sep 2024.
Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young & aged mice. Cell Report Medicine, Aug 2023.
A complex epigenome-splicing crosstalk governs epithelial to mesenchymal transition in metastasis and brain development. Nature Cell Biology. Aug 2022.
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice. Nature Aging. Mar 2022.
FBXO32 is an upstream regulator of epigenetic and transcriptional reprograming underlying EMT. Nature Communication. Aug 2017.
Dynamics and function of distal regulatory elements during neurogenesis and neuroplasticity. Genome Res. Sep 2015.
JNK-dependent gene regulatory circuitry governs mesenchymal fate. EMBO Journal. Aug 2015.

Post doctoral projectThe successful candidate will work on a highly interdisciplinary project focused on deciphering the genetic and epigenetic basis of aging and its misregulation in diseases such as fibrosis. You will employ technologies including:

Single-cell RNA-seq, and spatial transcriptomics
Genome-wide CRISPR screening in both in vitro and in vivo disease models

The project will involve identifying gene regulatory networks driving age-related phenotypes and exploring therapeutic targets for intervention. Responsibilities

Investigate gene regulatory mechanisms underlying aging and misregulation in age-associated pathologies.
Perform in vitro and in vivo experiments as needed, including single-cell sequencing and CRISPR-based screenings.
Maintain accurate and detailed records of research activities.
Collaborate with internal and external partners across various fields, including genomics, bioinformatics, and biomedicine.
Contribute to the publication of research findings in high-impact journals.
Gain hands-on training in cutting-edge and multidisciplinary research.

Required qualifications

PhD in molecular biology, biomedicine, biochemistry, or a related field.
Experience in genomics tool.
Strong analytical, organizational, and record-keeping skills.
Good communication skill in english
Interest in working in a multidisciplinary and multicultural team.
Willingness to collaborate with both internal and external partners.

We offer

High-impact, interdisciplinary research opportunities.
A stimulating, international work environment.
Full funding for two years.
Advanced training and career development support.
Access to state-of-the-art equipment and research facilities.
Competitive salary and benefits, including health coverage and social security.
Practical, legal, and social support (housing, visa, tax) through SDU’s International Staff Office (ISO).

Further informationFor more information or informal inquiries, contact Dr. Sanjeeb Kumar Sahu at .Application deadlineMay 25, 2025, at 23.59 hrs. CESTSalary and terms of employmentThe successful applicant for the postdoc position will be employed in accordance with the agreement between the Danish Ministry of Finance and AC (the Danish Confederation of Professional Associations).ApplicationApplications must be submitted electronically using the link “Apply now” – see below.We strongly recommend that you read before you apply.Only applications written in English will be accepted for evaluation.The application must include (as PDF files) (please note that the application (the motivation letter) and CV must not exceed 10 MB in total):

a motivation letter
a detailed CV including contact information
degree certificates (inclusive of Ph.D.-diploma)
a complete and numbered list of publications

Please note that all the above-mentioned information must be included in the application. Incomplete applications will not be assessed.If you experience technical problems, you must contact .Applications may be shortlisted.Living and working in DenmarkForeign applicants will be offered as part of the employment.The (ISO) at SDU provides a variety of services for new employees, guests and people who are considering applying for a job at the University of Southern Denmark.The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Salariu așteptat

Locație

Odense, Syddanmark

Data jobului

Fri, 09 May 2025 03:59:16 GMT

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