Scientist- Immuno Oncology

Job title:

Scientist- Immuno Oncology

Company

Orion Pharma

Job description

Job Description:About your roleIn this role you will contribute to IO target identification and validation, coupled with being responsible for supporting IO drug discovery projects. In this role you have a unique opportunity to contribute to a range of treatment modalities ranging from small molecules, bispecific antibodies and CAR T cells.Your key responsibilities

• Design and perform in vitro/ex vivo immune cell assays and treatment with oncology drugs in conjunction with internal project teams.
• Establish and validate human in vitro and ex.vivo primary immune cells assays to define the mechanism of action of IO drugs.
• Provide expert knowledge of tumour biology and tumour immunology to the organisation.
• Co-ordinate with the line-manager to ensure timely delivery of data and report if any issues encountered or foreseen.
• Be responsible person for CRO and external partnered studies.
• Develop and implement novel primary immune cells assay to improve the target confidence and in vitro pharmacology data package.
• Provide clear reports and presentations as required and participate in project team meetings and organisation meetings.
• Liaise with data science team to establish and validated potential biomarkers.
• Working in close collaboration with other scientists and technicians.

The location for the role is Turku and we will support relocation to Finland. You can work flexibly in a hybrid model in accordance with Orion’s relevant guidelines.What we offerAt Orion, your work creates true impact and well-being for our customers, patients and society at large. ​ ​Our culture of friendliness, respect, mutual appreciation and diversity creates a safe working environment where you can strive for excellence. We offer a wealth of career paths and development opportunities that support the development of innovative solutions and improving the quality of life.Please visit our website to find further information about our values and Orion as an employer .Our expectationsEssential competences, education and way of working include the following:

• PhD degree in Immunology, Immuno oncology or related field with 3+ years of Industry or academic experience.
• Strong and deep knowledge in Immuno oncology, cancer immunotherapy, immune cell signalling as evidenced by high impact journal publication or poster presentation.
• Previous experience in pharma or biotech with bispecific antibodies is a plus.
• Strong in vitro and ex.vivo research experience using primary immune cells from cancer patient samples is a must
• Demonstrate ability to independently design, conduct and interpret the data from complex immune cell assays.
• Demonstrate proficiency in isolation of immune cells and processing samples for multi-colour flow cytometry, multiplex ELISA, IHC, single cell RNA sequencing and gene expression analysis.
• Competency in using graph pad prism, flowjo, nSolver software and other standard office software.
• Excellent attention to details with strong communication skills.
• Flexibility and willingness to learn new techniques and take additional responsibilities as a member of the research team.

How to apply and additional informationWe look forward to receiving your CV and application in English by 2nd March 2025 at the latest.For further information, please contact Dr Anil Thotakura, Head of Immuno-Oncology, .#LI-ORIONApproved medical examination which also includes drug testing is required prior to the employment.Unit descriptionOrion’s pharmaceutical innovations are created within its R&D organization. We employ around 400 top professionals in the field of drug discovery and development. We work globally: in Espoo and Turku in Finland, in Nottingham in England and in New York, NY, USA. Orion R&D and the Innovative Medicines business division are dedicated to making a transformation to become a global player in the pain and oncology therapy areas.Immuno-Oncology (IO) is one of the three Research teams in Orion’s Oncology R&D. IO team is accountable for novel drug discovery projects, identification of unmet need, identification & experimental validation of potential IO drug targets within state-of-the-art laboratories and technologies.About Us:Orion is a globally operating Finnish pharmaceutical company – a builder of well-being for over a hundred years.Orion provides meaningful work for more than 3 600 Orionees in Finland and abroad. Orion is known as a responsible and reliable employer where we value each other, strive for the best and build for tomorrow.We develop, manufacture and market human and veterinary pharmaceuticals and active pharmaceutical ingredients. Orion has an extensive portfolio of proprietary and generic medicines and consumer health products. The core therapy areas of our pharmaceutical R&D are oncology and pain. Proprietary products developed by Orion are used to treat cancer, neurological diseases and respiratory diseases, among others.

Expected salary

Location

Turku, Varsinais-Suomi

Job date

Thu, 13 Feb 2025 03:45:04 GMT

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