Scientist MDS Upstream (Microbial Drug Substance)

Job title:

Scientist MDS Upstream (Microbial Drug Substance)

Company

GlaxoSmithKline

Job description

Job PurposeAs a Scientist specialized in upstream/fermentation field, you will join a team of experts dedicated to developing drug substance processes for new vaccine candidates, from Phase I to commercial launch. Additionally, you will engage in life cycle activities to improve processes within the commercial vaccine portfolio.The successful candidate will report to the Head of Development Unit 5 within the Microbial Drug Substance department in Belgium, part of the Global Drug Substance organization in Technical R&D (TRD).Your Responsibilities:

• Experimental Design and Execution: Support the upstream team by autonomously designing and conducting experiments in the lab (spending approximately 70% of your time in the lab and 30% on administrative tasks, including cross-functional scientific discussions). Implement the latest industry trends and state-of-the-art technologies to enhance current manufacturing processes, aiming for scalable, high-efficiency, robust, and cost-effective methods with a reduced footprint.
• Analytical Strategy: Collaborate with the In-Process Analytical organization to develop and implement IPA strategies and testing for downstream processes.
• Project Management: Demonstrate project management skills by performing timeline and resource planning, planning experimental protocols, and leading horizontally a team of technicians. Maintain a strong lab presence to ensure best practices, compliance with documentation, and adherence to EHS standards.
• Collaboration: ensure a strong interface and knowledge sharing with Manufacturing Science and Technology, manufacturing strategy, site management, Process Science, and engineering departments for building related activities such as revamping, scaling-up or tech transfer to new facilities. Build strong relationships and a collaborative network with the DS organizations in Italy and US stimulating people development and pushing top science & technology throughout the network.
• Documentation: Write and review project reports, including process history files and process development reports.
• Quality by Design: Follow the Quality by Design approach to process development. Lead multi-disciplinary Technical Risk Assessments and ensure all documentation deliverables are met at each project stage gate.
• Team Development: Support the Development Unit Head in elevating the technical knowledge and best practices of the team, both within your unit and across other units in the department. Proactively promote initiatives.
• Scale-Up Coordination: Work closely with the Scale-up team during development stages to ensure smooth transitions across different project phases.

Why You?Basic QualificationsEducational background: Master’s degree in bio-engineering, biochemistry, biotechnology, chemistry, or a related field. PhD is a plus. * Experience: hands-on experience in microbial fermentation, particularly with E. coli and yeast. Proven experience in recombinant protein, polysaccharide, plasmid expression. Demonstrated expertise in tangential filtration, centrifugation, and other techniques of separation.

• Technical interest: Deep interest in the technical aspects of the job and a willingness to participate actively on the shopfloor.
• Scientific Skills: Strong scientific methodology, critical thinking, and problem-solving abilities.
• Communication: Strong communication skills, both written and spoken in English, scientifically/technically as well as conversationally. Being able to communicate in French.
• Adaptability: Ability to work in a dynamic, multidisciplinary environment and embrace change positively.
• Proactivity: Demonstrated ability to be proactive, take initiative, and lead autonomously.
• Excellence: Imprinted with a desire for rigor, excellence, optimistic, and open-minded.
• Leadership: Motivated by process development from lab scale to manufacturing scale, with the ability to lead both in the lab and manage a small team of technicians.

Preferred qualifications:

• Proficiency in operating Ambr, DasGip, and fermentation systems.
• Experience with fermentation monitoring and data analysis using HPLC, GC, spectroscopy, pH, DO, or any other relevant methodologies.
• Experience in Vaccines Drug Substance development and/or manufacturing (Product & Process Expert or similar).
• Strong understanding of clinical and commercial Manufacturing processes and manufacturing constraints.
• Strong understanding and knowledge of process industrialization methods.
• Strong understanding of the industry trends and a compelling vision of next-generation and vaccine and biopharmaceutical development and manufacturing.
• Understanding in continuous manufacturing, high throughput , big data, multivariate analysis, predictive analytics and modelling approaches.

If you have a disability and require assistance during the course of the selection process, you will have the opportunity to let us know what specific assistance you require in order to make suitable arrangements.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Expected salary

Location

Rixensart, Waals Brabant

Job date

Thu, 21 Nov 2024 05:14:34 GMT

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